The ubiquitin-like modifier FAT10 stimulates the activity of deubiquitylating enzyme OTUB1

Functional analysis of the ubiquitin-like modifier FAT10 in autophagy

The Ubiquitin-like modifier FAT10 in tolerance induction

III I have made the most important discovery of my career, the most important discovery of my life. It is only in the mysterious equations of love that any logic or reasons can be found. cited from " A beautiful mind " IV Acknowledgement I would like to express my gratitude to Marcus Groettrup for taking me back with open arms in the lab after failure of the " French adventure " , his constant ...

Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation

The ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) directly targets its substrates for proteasomal degradation by becoming covalently attached via its C-terminal diglycine motif to internal lysine residues of its substrate proteins. The conjugation machinery consists of the bispecific E1 activating enzyme Ubiquitin-like modifier activating enzyme 6 (UBA6), the likewise bispecific ...

The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense.

The ubiquitin-like modifier (ULM) HLA-F adjacent transcript 10 (FAT10) is encoded in the MHC locus, is up-regulated during dendritic cell maturation, is highly expressed in lymphoid tissues, and strongly induced by interferon (IFN)-γ and tumor necrosis factor (TNF)-α. FAT10 is the only ULM known to date which directly targets its hundreds of substrates for degradation by the proteasome. This im...

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.

During misfolded-protein stress, the cytoplasmic protein histone deacetylase 6 (HDAC6) functions as a linker between the dynein motor and polyubiquitin to mediate the transport of polyubiquitylated cargo to the aggresome. Here, we identify a new binding partner of HDAC6, the ubiquitin-like modifier FAT10 (also known as UBD), which is cytokine-inducible and - similar to ubiquitin - serves as a s...